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Description for Protein ATP8A1

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; phosphoproteome: 1; platelet: 4; undefined: 1)
Summary:
The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.3.1
    KEGG - Orthology:
    K01530
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ATPIA; ATPP2; ATPASEII; Chromaffin granule ATPase II; Aminophospholipid translocase; ATPase class I type 8A member 1; Potential phospholipid-transporting ATPase IA; ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
    Approved Symbol:
    ATP8A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphatidylserine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 8
  • Isoform 1 : 8
    • Additional Identifiers:

    HPRD: 16527 Entrez Gene ID: 10396 OMIM ID: 609542 Swissprot Accession: Q9Y2Q0; Q32M36; Q32M35;