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Description for Protein DLC1

deleted in liver cancer 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SAM: Sterile alpha motif.
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
  • START: in StAR and phosphatidylcholine transfer protein
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    START domain containing 12; Deleted in liver cancer 1; HP protein; StAR related lipid transfer protein 12; StARD12; KIAA1723; Deleted in liver cancer 1 isoform 1; Deleted in liver cancer 1 isoform 2; Deleted in liver cancer 1 isoform 3; p122-RhoGAP; FLJ21120; ARHGAP7; HP
    Approved Symbol:
    DLC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Colorectal cancer, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05035 Entrez Gene ID: 10395 OMIM ID: 604258 Swissprot Accession: B4DR10; Q96QB1; A8K119;