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Description for Protein WARS2

tryptophanyl tRNA synthetase 2, mitochondrial
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.1.1.2
    KEGG - Orthology:
    K01867
    KEGG - Pathway(s):
    hsa00380; hsa00970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Tryptophanyl tRNA synthetase 2 (mitochondrial); (Mt)TrpRS; mitochondrial tryptophanyl tRNA synthetase 2 isoform 1 precursor; mitochondrial tryptophanyl tRNA synthetase 2 isoform 2 precursor
    Approved Symbol:
    WARS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • L-Tryptophan(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05295 Entrez Gene ID: 10352 OMIM ID: 604733 Swissprot Accession: Q9UGM6; B1ALR1;