Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CLEC4M

C-type lectin domain family 4, member M
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants. (PubMed Links)
Domains and Motifs:
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06563
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DC-SIGN related protein; HP10347; DCSIGN2; LSIGN; Liver/lymph node specific ICAM 3 grabbing nonintegrin; Probable mannose binding C type lectin DCSIGNR; Dendritic cell specific ICAM 3 grabbing nonintegrin 2; Type II membrane protein similar to HIV gp120 binding C type lectin; C-type lectin domain family 4, member M isoform 2; C-type lectin domain family 4, member M isoform 4; MGC129964; CD209L; MGC47866; DC-SIGNR; CD299; CD209 antigen-like; CD209 antigen-like protein 1; C-type lectin domain family 4, member M isoform 1; C-type lectin domain family 4, member M isoform 3
    Approved Symbol:
    CLEC4M
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    12060_14(1)
    12060_13(1)
    12060_12(1)
    12060_11(1)
    12060_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 1
  • Isoform 7 : 1
  • Isoform 6 : 0
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 12060 Entrez Gene ID: 10332 OMIM ID: 605872 Swissprot Accession: Q9H2X3; B4E2Z5;