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Description for Protein AKR1A1

aldo-keto reductase family 1, member A1 (aldehyde reductase)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(platelet: 4; secretome: 1)
Summary:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Alternative splicing of this gene results in two transcript variants encoding the same protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.2
KEGG - Orthology:
K00002
KEGG - Pathway(s):
hsa00010; hsa00561; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Aldo-keto reductase family 1, member A1; ALR; ALDR1; Alcohol dehydrogenase [NADP+]; EC 1.1.1.2
Approved Symbol:
AKR1A1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Tolrestat(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00069 Entrez Gene ID: 10327 OMIM ID: 103830 Swissprot Accession: P14550;