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Description for Protein CDKN2C

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
15 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06622
    KEGG - Pathway(s):
    hsa04110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cyclin dependent kinase 6 inhibitor; Cyclin dependent kinase 4 inhibitor C; Cyclin dependent inhibitor; CDK6 inhibitor p18; p18-INK6; p18-INK4c; CDKN6; p18(INK4C); INK4C; p18; Cyclin-dependent kinase 6 inhibitor p18
    Approved Symbol:
    CDKN2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04534 Entrez Gene ID: 1031 OMIM ID: 603369 Swissprot Accession: P42773; Q6ICV4;