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Description for Protein CDKN2B

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04685
KEGG - Pathway(s):
hsa04110; hsa04350; hsa05200; hsa05222
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Multiple tumor suppressor 2; MTS2; p15INK4B; TP15; CDK4B Inhibitor; Cyclin dependent kinase 4 inhibitor B; p14 INK4b; p15 INK4b; Cyclin-dependent kinase inhibitor 2B isoform 2; Cyclin-dependent kinase inhibitor 2B isoform 1
Approved Symbol:
CDKN2B
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02696 Entrez Gene ID: 1030 OMIM ID: 600431 Swissprot Accession: P42772; O15125;