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Description for Protein ADAR

adenosine deaminase, RNA-specific
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
  • DSRM: Double-stranded RNA binding motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.5.4.-
    KEGG - Orthology:
    K12968
    KEGG - Pathway(s):
    hsa04623
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DRADA; Adenosine deaminase, RNA specific 1; Interferon inducible protein 4; ADAR1; DSRAD; 136 kDa double stranded RNA binding protein; Adenosine deaminase RNA-specific isoform ADAR-a; P136; K88DSRBP; IFI-4 protein; Adenosine deaminase, RNA-specific isoform a; Adenosine deaminase, RNA-specific isoform b; Adenosine deaminase, RNA-specific isoform c; Adenosine deaminase, RNA-specific isoform d; DSH; Double-stranded RNA-specific adenosine deaminase
    Approved Symbol:
    ADAR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Dyschromatosis symmetrica hereditaria(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07528 Entrez Gene ID: 103 OMIM ID: 146920 Swissprot Accession: Q59EC0; P55265;