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Description for Protein PAK4

p21 protein (Cdc42/Rac)-activated kinase 4
16 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PBD: P21-Rho-binding domain
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K05734
    KEGG - Pathway(s):
    hsa04012; hsa04360; hsa04510; hsa04660; hsa04810; hsa05211
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Serine/threonine protein kinase PAK 4; EC 2.7.1.37; p21 activated kinase 4 isoform 1; p21 activated kinase 4 isoform 2
    Approved Symbol:
    PAK4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 34
    Human (de-) phosphorylation sites: 34; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 25
    Human phosphorylation targets: 4; Predicted platelet targets: 21
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05675 Entrez Gene ID: 10298 OMIM ID: 605451 Swissprot Accession: O96013;