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Description for Protein CDKN1B

cyclin-dependent kinase inhibitor 1B (p27, Kip1)
58 total interacting proteins; 32 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06624
    KEGG - Pathway(s):
    hsa04012; hsa04110; hsa05200; hsa05215; hsa05220; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cyclin dependent kinase inhibitor p27; p27Kip1; KIP1; CDKN4
    Approved Symbol:
    CDKN1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Multiple endocrine neoplasia, type IB(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02867 Entrez Gene ID: 1027 OMIM ID: 600778 Swissprot Accession: P46527; Q6I9V6;