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Description for Protein ZMPSTE24

zinc metallopeptidase (STE24 homolog, S. cerevisiae)
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; platelet: 2)
Summary:
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.84
    KEGG - Orthology:
    K06013
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    STE24; FACE1; Ste24p; FLJ14968; CAAX prenyl protease; Prenyl protein specific endoprotease 1; Farnesylated proteins converting enzyme 1
    Approved Symbol:
    ZMPSTE24
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Mandibuloacral dysplasia with type B lipodystrophy(Pd);
  • Restrictive dermopathy, lethal(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 07349 Entrez Gene ID: 10269 OMIM ID: 606480 Swissprot Accession: O75844;