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Description for Protein CDKN1A

cyclin-dependent kinase inhibitor 1A (p21, Cip1)
96 total interacting proteins; 36 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06625
    KEGG - Pathway(s):
    hsa04012; hsa04110; hsa04115; hsa05200; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Melanoma differentiation associated protein 6; CDKN1; p21CIP1; CIP 1; WAF1; MDA 6; p21; SDI1; CAP20; PIC1; DNA synthesis inhibitor; CDK-interaction protein 1; Wild-type p53 activated fragment 1; Cyclin dependent kinase inhibitor 1
    Approved Symbol:
    CDKN1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • CIP1/WAF1 tumor-associated polymorphism 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00298 Entrez Gene ID: 1026 OMIM ID: 116899 Swissprot Accession: P38936; Q6FI05;