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Description for Protein STAM2

signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
18 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • VHS: Domain present in VPS-27, Hrs and STAM
  • UIM: Ubiquitin-interacting motif.
  • SH3: Src homology 3 domains
  • CC: Coiled Coil
  • ITAM: Immunoreceptor tyrosine-based activation motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04705
    KEGG - Pathway(s):
    hsa04144; hsa04630
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Signal transducing adaptor molecule 2A; Signal transducing adaptor molecule 2B; Signal transducing adaptor molecule 2; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
    Approved Symbol:
    STAM2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05876 Entrez Gene ID: 10254 OMIM ID: 606244 Swissprot Accession: O75886;