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Description for Protein RASGRP2

RAS guanyl releasing protein 2 (calcium and DAG-regulated)
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/1)
(membrane: 2; platelet: 18)
Summary:
The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
  • EF: EF-hand, calcium binding motif
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12361
    KEGG - Pathway(s):
    hsa04010; hsa04062
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CDC25L; CALDAG-GEFI; CDC25-like gene; Guanine exchange factor MCG7; Calcium and DAG-regulated guanine nucleotide exchange factor I; Calcium and diacylglycerol-regulated guanine nucleotide exchange factor 1
    Approved Symbol:
    RASGRP2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09278 Entrez Gene ID: 10235 OMIM ID: 605577 Swissprot Accession: Q7LDG7;