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Description for Protein CDK7

cyclin-dependent kinase 7
38 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.22
    KEGG - Orthology:
    K02202
    KEGG - Pathway(s):
    hsa03420; hsa04110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CAK1; STK1; CDKN7; p39MO15; Cdk activating kinase; 39 KDa protein kinase; Kinase subunit of CAK; Serine/threonine kinase stk1; Cell division protein kinase 7; Serine/threonine protein kinase 1; Serine/threonine protein kinase MO15; TFIIH basal transcription factor complex kinase subunit
    Approved Symbol:
    CDK7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 15
    Human phosphorylation targets: 15; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Flavopiridol(db);
  • Phosphonothreonine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 15993 Entrez Gene ID: 1022 OMIM ID: 601955 Swissprot Accession: P50613;