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Description for Protein ADAM10

ADAM metallopeptidase domain 10
10 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(membrane: 1; microparticles: 1; platelet: 2; undefined: 1)
Summary:
Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • REP: Replication protein
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.24.81
    KEGG - Orthology:
    K06704
    KEGG - Pathway(s):
    hsa05010; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    A disintegrin and metalloproteinase domain 10; Kuz; MADM; Kuzbanian; HsT18717; EC 3.4.24.81; CDw156; AD10; CD156c
    Approved Symbol:
    ADAM10
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03723 Entrez Gene ID: 102 OMIM ID: 602192 Swissprot Accession: O14672;