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Description for Protein SORBS3

sorbin and SH3 domain containing 3
23 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The SORBS3 gene encodes 2 isoforms vinexin-alpha and -beta that are vinculin (VCL; MIM 193065)-binding cytoskeletal proteins involved in focal adhesion and cell-cell adhesion (Kioka et al., 1999 [PubMed 9885244]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • SORB: Sorbin homologous domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SH3D4; Vinexin; Vinexin beta (SH3-containing adaptor molecule-1) isoform 2; Vinexin beta (SH3-containing adaptor molecule-1) isoform 1; SH3 containing adaptor molecule 1; Vinculin binding protein; SCAM 1; Vinexin beta (SH3 containing adaptor molecule 1); Sorbin and SH3 domain containing 3
    Approved Symbol:
    SORBS3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 39
    Human (de-) phosphorylation sites: 39; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 11535 Entrez Gene ID: 10174 OMIM ID: 610795 Swissprot Accession: O60504; Q96FY4;