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Description for Protein WASF2

WAS protein family, member 2
20 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; platelet: 3)
Summary:
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • WH2: Wiskott Aldrich syndrome homology region 2
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05748
    KEGG - Pathway(s):
    hsa04520; hsa04666; hsa04810; hsa05100; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    WASP family, member 2; WASP family, Verprolin homology domain containing protein 2; WAVE2; SCAR; SCAR2; dJ393P12.2; IMD2; Suppressor of cyclic-AMP receptor
    Approved Symbol:
    WASF2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05796 Entrez Gene ID: 10163 OMIM ID: 605875 Swissprot Accession: Q8NBU0; Q9Y6W5; Q8IV90;