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Description for Protein RASGRP1

RAS guanyl releasing protein 1 (calcium and DAG-regulated)
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RasGEF: Guanine nucleotide exchange factor for Ras-like small GTPases
  • EF: EF-hand, calcium binding motif
  • RasGEFN: Guanine nucleotide exchange factor for Ras-like GTPases
  • N-terminal motif
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04350
    KEGG - Pathway(s):
    hsa04010; hsa04660
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RAS guanyl releasing protein 1; Calcium and diacylglycerol dependent (CalDAG)GEF1; RasGRP1; RasGRP
    Approved Symbol:
    RASGRP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04909 Entrez Gene ID: 10125 OMIM ID: 603962 Swissprot Accession: O95267; B2RA89;