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Description for Protein ARPC2

actin related protein 2/3 complex, subunit 2, 34kDa
8 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(membrane: 1; microparticles: 1; platelet: 7; secretome: 1; undefined: 1)
Summary:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K05758
KEGG - Pathway(s):
hsa04666; hsa04810; hsa05100; hsa05130; hsa05131
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ARP2/3 protein complex subunit 34; Actin related protein 2/3 complex subunit 2; ARP2/3 complex 34 kDa subunit; ARC34; PRO2446; p34 Arc; PNAS139
Approved Symbol:
ARPC2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one(db);
  • N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10367 Entrez Gene ID: 10109 OMIM ID: 604224 Swissprot Accession: O15144; Q53R19;