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Description for Protein PPIF

peptidylprolyl isomerase F
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/1)
(membrane: 1; microparticles: 1; platelet: 8)
Summary:
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.2.1.8
KEGG - Orthology:
K09565
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Cyclophilin 3; Cyclophilin F; CYP3; Rotamase; PPIase
Approved Symbol:
PPIF
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane(db);
  • 7-AMINO-4-METHYL-CHROMEN-2-ONE(db);
  • Dimethyl sulfoxide(db);
  • L-Proline(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06839 Entrez Gene ID: 10105 OMIM ID: 604486 Swissprot Accession: P30405;