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Description for Protein ARPC1B

actin related protein 2/3 complex, subunit 1B, 41kDa
10 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/3)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 13; secretome: 1; undefined: 2)
Summary:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • WD40: WD40 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05757
    KEGG - Pathway(s):
    hsa04666; hsa04810; hsa05100; hsa05130; hsa05131
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Actin related protein 2/3 complex subunit 1B; Actin related protein 2/3 complex, subunit 1A (41 kD); ARC41; p40-ARC; p41-ARC; ARP2/3 protein complex subunit p41; Actin related protein 2/3 complex, subunit 1B, 41kDa
    Approved Symbol:
    ARPC1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one(db);
  • N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10366 Entrez Gene ID: 10095 OMIM ID: 604223 Swissprot Accession: O15143; A4D275;