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Description for Protein ARPC3

actin related protein 2/3 complex, subunit 3, 21kDa
18 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/3)
(alpha granules: 1; membrane: 1; platelet: 5; secretome: 1; undefined: 2)
Summary:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K05756
KEGG - Pathway(s):
hsa04666; hsa04810; hsa05100; hsa05130; hsa05131
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Actin related protein 2/3 complex, subunit 3; p21-Arc; Actin related protein 2/3 complex, subunit 3, 21kDa; ARC21
Approved Symbol:
ARPC3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one(db);
  • N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09175 Entrez Gene ID: 10094 OMIM ID: 604225 Swissprot Accession: O15145;