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Description for Protein ARPC4

actin related protein 2/3 complex, subunit 4, 20kDa
11 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/2)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 5; secretome: 1; undefined: 1)
Summary:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K05755
KEGG - Pathway(s):
hsa04666; hsa04810; hsa05100; hsa05130; hsa05131
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
p20 Arc; MGC13544; Arp 2/3 protein complex subunit p20; ARC20; Actin related protein 2/3 complex subunit 4 isoform a; Actin related protein 2/3 complex subunit 4 isoform b
Approved Symbol:
ARPC4
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one(db);
  • N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10368 Entrez Gene ID: 10093 OMIM ID: 604226 Swissprot Accession: P59998; C9JJ59;