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Description for Protein HUWE1

HECT, UBA and WWE domain containing 1
20 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • UBA: Ubiquitin associated domain
  • UIM: Ubiquitin-interacting motif.
  • WWE: Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K10592
    KEGG - Pathway(s):
    hsa04120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UREB1; HECT domain protein LASU1
    Approved Symbol:
    HUWE1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 66
    Human (de-) phosphorylation sites: 66; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06608 Entrez Gene ID: 10075 OMIM ID: 300697 Swissprot Accession: Q7Z6Z7;