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Description for Protein DPP3

dipeptidyl-peptidase 3
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(microparticles: 1; platelet: 1; secretome: 1)
Summary:
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.4.14.4
KEGG - Orthology:
K01277
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Dipeptidylpeptidase III isoform 2; Dipeptidyl arylamidase 3; Dipeptidyl aminopeptidase 3
Approved Symbol:
DPP3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06012 Entrez Gene ID: 10072 OMIM ID: 606818 Swissprot Accession: Q9NY33; Q53GT4; Q5JPB8;