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Description for Protein ABCC9

ATP-binding cassette, sub-family C (CFTR/MRP), member 9
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. No disease has been associated with this gene thus far. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • AAA: ATPases associated with a variety of cellular activities
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05033
    KEGG - Pathway(s):
    hsa02010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sulfonylurea receptor 2; SUR2; ABC37; FLJ36852; ATP-binding cassette, sub-family C, member 9 isoform SUR2A; ATP-binding cassette, sub-family C, member 9 isoform SUR2B; ATP-binding cassette, sub-family C, member 9 isoform SUR2A-delta-14
    Approved Symbol:
    ABCC9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db);
  • Glibenclamide(db)

    Associated Genetic Diseases:

  • Cardiomyopathy, dilated, 1o(Pd)
    		• Predicted Transmembrane Domains:
    03258_3(14)
    03258_2(14)
    03258_1(14)
    Additional Identifiers:

    HPRD: 03258 Entrez Gene ID: 10060 OMIM ID: 601439 Swissprot Accession: O60706; A6NFG0;