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Description for Protein DNM1L

dynamin 1-like
13 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/1)
(membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 7; secretome: 5; undefined: 1)
Summary:
The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DYNC: Dynamin, GTPase
  • GED: Dynamin GTPase effector domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.5.5
    KEGG - Orthology:
    K01528
    KEGG - Pathway(s):
    hsa04144; hsa04666; hsa05100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Dynamin 1 like; DRP1; DVLP; Dynamin family member proline rich c terminal domain less DYMPLE; Dynamin like protein 4; DLP1; VPS1; DYMPLE; HDYNIV; Dynamin-like protein; EC 3.6.5.5; Dnm1p/Vps1p-like protein; Dynamin family member proline-rich carboxyl-terminal domain less; Dynamin 1-like protein isoform 3; Dynamin 1-like protein isoform 1; Dynamin 1-like protein isoform 2
    Approved Symbol:
    DNM1L
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; Platelet phosphorylation sites: 3
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04833 Entrez Gene ID: 10059 OMIM ID: 603850 Swissprot Accession: Q59GN9; O00429;