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Description for Protein SAE1

SUMO1 activating enzyme subunit 1
11 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.3.2.19
KEGG - Orthology:
K10684
KEGG - Pathway(s):
hsa04120
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
HSPC140; Ubiquitin like 1 activating enzyme E1A; UBLE1A; SUMO 1 activating enzyme E1 N subunit; SAE1; AOS1; SUA1
Approved Symbol:
SAE1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 18010 Entrez Gene ID: 10055 OMIM ID: 613294 Swissprot Accession: B3KMQ2; Q9UBE0;