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Description for Protein ABI1

abl-interactor 1
28 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(phosphoproteome: 1; platelet: 13; undefined: 1)
Summary:
The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Eps8 binding protein; E3B1; Spectrin SH3 domain binding protein 1; ABI1/MLL fusion gene; Nap1 binding protein; Interactor protein Ablbp4; NAP1BP; SSH3BP; SSH3BP1; Abelson interactor 1; Abl-interactor protein 1 long; Abl-interactor 1 isoform a; Abl-interactor 1 isoform b; Abl-interactor 1 isoform d; Abl-interactor 1 isoform c
    Approved Symbol:
    ABI1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 85
    Human (de-) phosphorylation sites: 85; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04336 Entrez Gene ID: 10006 OMIM ID: 603050 Swissprot Accession: Q8IZP0;