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Description for Protein AKT3

v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
6 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04456
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04150; hsa04210; hsa04370; hsa04510; hsa04530; hsa04620; hsa04630; hsa04660; hsa04662; hsa04664; hsa04666; hsa04722; hsa04910; hsa04914; hsa04920; hsa05142; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RAC gamma serine/threonine protein kinase; RACPK gamma; Protein kinase Akt3; Protein kinase B, gamma; PKB gamma; PKBG; PRKBG; STK-2; RAC-gamma; DKFZP434N0250; Serine threonine protein kinase, Akt-3; V-akt murine thymoma viral oncogene homolog 3 isoform 1; V-akt murine thymoma viral oncogene homolog 3 isoform 2
    Approved Symbol:
    AKT3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06441 Entrez Gene ID: 10000 OMIM ID: 611223 Swissprot Accession: Q9Y243;