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Description for Protein NAT2

N-acetyltransferase 2 (arylamine N-acetyltransferase)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.5
    KEGG - Orthology:
    K00622
    KEGG - Pathway(s):
    hsa00232; hsa00983; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Arylamine N-acetyltransferase 2; AAC2; ARY2; PNAT; N-acetyltransferase type 2; Acetyl CoA, arylamine N-acetyltransferase
    Approved Symbol:
    NAT2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Acetylation, slow(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02000 Entrez Gene ID: 10 OMIM ID: 612182 Swissprot Accession: P11245; A4Z6T7;